Can I have a glass of wine while taking amoxicillin?

Can You Drink Wine While on Amoxicillin?

Good news if you're prescribed amoxicillin and were wondering about that glass of wine: yes, it’s generally safe to drink alcohol while taking this common antibiotic. Unlike some other medications, alcohol doesn’t interfere with amoxicillin’s ability to fight bacterial infections. Whether you're treating a sinus infection, bronchitis, or a skin condition, the antibiotic will still work effectively even if you enjoy a moderate amount of wine.

That said, moderation is crucial. While a single glass likely won’t cause harm, heavier drinking can weaken your immune system and slow recovery. Your body is already working hard to fend off infection—adding alcohol into the mix may leave you feeling more fatigued, dehydrated, or unwell. Some people also report nausea or stomach upset when combining alcohol with antibiotics, even if they’re not directly interacting.

Many doctors recommend avoiding alcohol altogether while on antibiotics—not because of a dangerous interaction, but because it supports your healing process. Rest, hydration, and letting your body focus on recovery are always the best tools when fighting illness. If you do choose to drink, keep it light and pay attention to how you feel.

In short: A small glass of wine probably won’t hurt, but skipping it might help you feel better faster. Always consult your healthcare provider if you have concerns, especially if you have liver issues or are taking other medications. When in doubt, err on the side of caution—your body will thank you.