What is Damon's biggest regret?

Matt Damon's Biggest Career Regret

Every actor has a missed opportunity or two in their past, but few carry a price tag quite like the one Matt Damon often talks about. When looking back over his storied career, his single biggest regret is turning down the lead role in James Cameron's original Avatar.

The decision wasn't just about passing on a blockbuster; it cost him a staggering financial payout. Because of a scheduling conflict with the Bourne franchise, Damon had to walk away from the project. Not only did he miss out on starring in what would become the highest-grossing film of all time, but he also passed up a deal that would have netted him 10 percent of the movie's monumental box office gross.

While Damon has joked in interviews about turning down more money than any other actor in history, it remains a genuinely nagging piece of "what-if" history in Hollywood. Even with an Oscar and dozens of iconic roles under his belt, leaving billions of dollars on the table is a tough pill to swallow.