What is the largest company with a woman CEO?

GM Leads as Top Fortune 500 Company Run by a Woman

While Walmart and Amazon continue to dominate the upper ranks of the Fortune 500, the highest spot held by a company led by a woman belongs to General Motors. Sitting at No. 18 on the list, GM is guided by CEO Mary Barra—a trailblazer in an arena where female leadership at the very top remains too rare.

Mary Barra took the helm at GM in 2014, becoming the first woman to lead a major global automaker. Under her leadership, the company has shifted gears—literally—pivoting from its traditional roots toward an all-electric future. Barra’s vision has not only redefined GM’s direction but also cemented her status as one of the most influential figures in corporate America.

It’s telling that in 2025, GM remains the most prominent example of a Fortune 500 company led by a woman. Despite decades of progress, women still hold just a fraction of CEO roles among the nation’s largest corporations. Barra’s consistent presence at the top is not just a personal achievement—it’s a milestone for gender equity in business.

Her leadership has weathered supply chain upheavals, industry transformation, and shifting consumer demands. Yet GM continues to innovate, with ambitious plans to phase out gas-powered vehicles entirely. That kind of long-term thinking, paired with steady execution, is what sets transformative leaders apart.

In a sea of corporate giants, Mary Barra’s GM doesn’t just hold its own—it stands out. Not because it’s the biggest, but because it’s led by someone reshaping what leadership looks like in modern America.