Mossy fibers project directly to the deep nuclei, but also give rise to the following pathway mossy fibers granule cells parallel fibers Purkinje cells deep nuclei.

In contrast, similar concentrations of lopinavir ritonavir demonstrated no repolarisation delay in the canine cardiac Purkinje fibres.

Thus, the dendrites of a Purkinje cell form a dense planar net, through which parallel fibers pass at right angles.

The superficial layer contains a set of GABAergic neurons called cartwheel cells that resemble Purkinje cells anatomically and chemically they receive parallel fiber input, but do not have any inputs that resemble climbing fibers.

Dasatinib activity in vitro in hERG and Purkinje fiber assays suggested a potential for prolongation of cardiac ventricular repolarization (QT interval).

Cardiac effects were observed in some non clinical studies in canines (prolongation of action potentials in Purkinje fibers or prolongation of the QTc interval).

Purkinje cells, or Purkinje neurons ( ), are a class of GABAergic neurons located in the cerebellum.

Similar concentrations of atazanavir increased by 13 the action potential duration (APD90) in rabbit Purkinje fibres study.

12 In similarity to some macrolides, telithromycin caused a prolongation of Qtc interval in dogs and on action potential duration in rabbit Purkinje fibers in vitro.

11 In similarity to some macrolides, telithromycin caused a prolongation of Qtc interval in dogs and on action potential duration in rabbit Purkinje fibers in vitro.

Most theories that assign learning to the circuitry of the cerebellum are derived from the ideas of David Marr and James Albus, who postulated that climbing fibers provide a teaching signal that induces synaptic modification in parallel fiber Purkinje cell synapses.

The large, spherical cell bodies of Purkinje cells are packed into a narrow layer (one cell thick) of the cerebellar cortex, called the Purkinje layer .

Because of the way that they are lined up longitudinally, the 1000 or so Purkinje cells belonging to a microzone may receive input from as many as 100 million parallel fibers, and focus their own output down to a group of less than 50 deep nuclear cells.

Albus proposed in 1971 that a cerebellar Purkinje cell functions as a perceptron, a neurally inspired abstract learning device.

A microzone is defined as a group of Purkinje cells all having the same somatotopic receptive field.

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Purkinje cells use GABA as their neurotransmitter, and therefore exert inhibitory effects on their targets.

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Granule cells Cerebellar granule cells, in contrast to Purkinje cells, are among the smallest neurons in the brain.

The branches of a climbing fiber (usually numbering about 10) usually innervate Purkinje cells belonging to the same microzone.

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Article 25

Cellular components Two types of neuron play dominant roles in the cerebellar circuit Purkinje cells and granule cells.

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Supratherapeutic concentrations of the active metabolite of fesoterodine, have been shown to inhibit K current in cloned human ether à go go related gene (hERG) channels and prolong action potential duration (70 and 90 repolarisation) in canine isolated Purkinje fibres.

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